1iwq Summary

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Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin

The structure was published by Yamauchi, E., Nakatsu, T., Matsubara, M., Kato, H., and Taniguchi, H., in 2003 in a paper entitled "Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca(2+)-calmodulin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CALMODULIN and MARCKS.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 93%
B MARCKS P26645 (148-166) (MARCS_MOUSE)search Mus musculussearch < 90% 19 94%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (2 - 149) CALMODULIN Homo sapiens
P26645 (148 - 166) MARCKS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B MARCKS familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62158) calcium ion bindingsearch nitric-oxide synthase regulator activitysearch phosphatidylinositol 3-kinase bindingsearch protein domain specific bindingsearch protein bindingsearch nitric-oxide synthase bindingsearch N-terminal myristoylation domain bindingsearch titin bindingsearch protein kinase bindingsearch thioesterase bindingsearch ion channel bindingsearch adenylate cyclase bindingsearch phospholipase bindingsearch protein phosphatase activator activitysearch enzyme regulator activitysearch calcium-dependent protein bindingsearch type 3 metabotropic glutamate receptor bindingsearch protein N-terminus bindingsearch metal ion bindingsearch protein serine/threonine kinase activator activitysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch inositol phosphate metabolic processsearch response to amphetaminesearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of protein autophosphorylationsearch regulation of rhodopsin mediated signaling pathwaysearch calcium-mediated signalingsearch blood coagulationsearch regulation of cytokinesissearch mitochondrion organizationsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch phototransduction, visible lightsearch innate immune responsesearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of nitric-oxide synthase activitysearch signal transductionsearch G-protein coupled receptor signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch platelet activationsearch carbohydrate metabolic processsearch positive regulation of phosphoprotein phosphatase activitysearch positive regulation of protein serine/threonine kinase activitysearch activation of adenylate cyclase activitysearch platelet degranulationsearch synaptic transmissionsearch positive regulation of nitric-oxide synthase activitysearch glucose metabolic processsearch pathogenesissearch positive regulation of protein dephosphorylationsearch nitric oxide metabolic processsearch response to corticosteronesearch detection of calcium ionsearch response to calcium ionsearch regulation of high voltage-gated calcium channel activitysearch negative regulation of peptidyl-threonine phosphorylationsearch membrane organizationsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch small molecule metabolic processsearch regulation of ryanodine-sensitive calcium-release channel activitysearch muscle contractionsearch epidermal growth factor receptor signaling pathwaysearch regulation of heart ratesearch Fc-epsilon receptor signaling pathwaysearch rhodopsin mediated signaling pathwaysearch organelle organizationsearch vascular endothelial growth factor receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch glycogen catabolic processsearch substantia nigra developmentsearch activation of phospholipase C activitysearch positive regulation of cyclic nucleotide metabolic processsearch regulation of cardiac muscle contractionsearch cytosolsearch nucleoplasmsearch plasma membranesearch spindle polesearch nucleussearch extracellular vesicular exosomesearch spindle microtubulesearch cytoplasmsearch neuron projectionsearch extracellular regionsearch sarcomeresearch calcium channel complexsearch spindlesearch growth conesearch vesiclesearch centrosomesearch cytoskeletonsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Myristoylated alanine-rich C-kinase substrate MARCKSsearch