1iwq Summary

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Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin

The structure was published by Yamauchi, E., Nakatsu, T., Matsubara, M., Kato, H., and Taniguchi, H., in 2003 in a paper entitled "Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca(2+)-calmodulin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CALMODULIN and MARCKS.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 93%
B MARCKS P26645 (148-166) (MARCS_MOUSE)search Mus musculussearch < 90% 19 94%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (2 - 149) CALMODULIN Homo sapiens
P26645 (148 - 166) MARCKS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B MARCKS familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62158) calcium ion bindingsearch protein bindingsearch protein domain specific bindingsearch calcium-dependent protein bindingsearch nitric-oxide synthase bindingsearch protein serine/threonine kinase activator activitysearch enzyme regulator activitysearch phosphatidylinositol 3-kinase bindingsearch phospholipase bindingsearch protein phosphatase activator activitysearch metal ion bindingsearch N-terminal myristoylation domain bindingsearch titin bindingsearch protein kinase bindingsearch nitric-oxide synthase regulator activitysearch adenylate cyclase bindingsearch thioesterase bindingsearch ion channel bindingsearch type 3 metabotropic glutamate receptor bindingsearch protein N-terminus bindingsearch positive regulation of phosphoprotein phosphatase activitysearch positive regulation of protein serine/threonine kinase activitysearch activation of adenylate cyclase activitysearch neurotrophin TRK receptor signaling pathwaysearch small molecule metabolic processsearch response to amphetaminesearch Fc-epsilon receptor signaling pathwaysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch membrane organizationsearch rhodopsin mediated signaling pathwaysearch activation of phospholipase C activitysearch regulation of nitric-oxide synthase activitysearch glycogen catabolic processsearch muscle contractionsearch epidermal growth factor receptor signaling pathwaysearch substantia nigra developmentsearch regulation of heart ratesearch regulation of ryanodine-sensitive calcium-release channel activitysearch synaptic transmissionsearch positive regulation of cyclic nucleotide metabolic processsearch regulation of cardiac muscle contractionsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch inositol phosphate metabolic processsearch phototransduction, visible lightsearch innate immune responsesearch platelet degranulationsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch response to corticosteronesearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of nitric-oxide synthase activitysearch signal transductionsearch positive regulation of protein autophosphorylationsearch regulation of cytokinesissearch regulation of rhodopsin mediated signaling pathwaysearch blood coagulationsearch nitric oxide metabolic processsearch detection of calcium ionsearch response to calcium ionsearch negative regulation of peptidyl-threonine phosphorylationsearch positive regulation of protein dephosphorylationsearch platelet activationsearch regulation of high voltage-gated calcium channel activitysearch glucose metabolic processsearch G-protein coupled receptor signaling pathwaysearch calcium-mediated signalingsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch carbohydrate metabolic processsearch positive regulation of peptidyl-threonine phosphorylationsearch extracellular regionsearch cytosolsearch spindle polesearch extracellular vesicular exosomesearch plasma membranesearch nucleoplasmsearch centrosomesearch vesiclesearch nucleussearch cytoplasmsearch spindle microtubulesearch spindlesearch growth conesearch cytoskeletonsearch sarcomeresearch calcium channel complexsearch neuron projectionsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Myristoylated alanine-rich C-kinase substrate MARCKSsearch