1iwg Summary

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Crystal structure of Bacterial Multidrug Efflux transporter AcrB

The structure was published by Murakami, S., Nakashima, R., Yamashita, E., and Yamaguchi, A., in 2002 in a paper entitled "Crystal structure of bacterial multidrug efflux transporter AcrB" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of AcrB. This molecule has the UniProt identifier P31224 (ACRB_ECOLI)search. The sample contained 1053 residues which is 100% of the natural sequence. Out of 1053 residues 1006 were observed and are deposited in the PDB.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AcrB P31224 (1-1049) (ACRB_ECOLI)search Escherichia coli K-12search 98% 1053 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P31224 (1 - 1049) AcrB Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P31224) Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomainssearch, Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomainssearch, Multidrug efflux transporter AcrB transmembrane domainsearch Multidrug efflux transporter AcrB transmembrane domainsearch, Multidrug efflux transporter AcrB pore domainsearch, Multidrug efflux transporter AcrB pore domain likesearch, Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomainssearch PF00873: AcrB/AcrD/AcrF familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P31224) transportsearch response to drugsearch drug exportsearch drug transmembrane transportsearch transporter activitysearch drug:proton antiporter activitysearch protein bindingsearch drug transmembrane transporter activitysearch membranesearch plasma membranesearch integral component of membranesearch integral component of plasma membranesearch

Chain InterPro annotation
A Acriflavin resistance proteinsearch Hydrophobe/amphiphile efflux-1 HAE1search Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomainssearch