1ivh Summary

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STRUCTURE OF HUMAN ISOVALERYL-COA DEHYDROGENASE AT 2.6 ANGSTROMS RESOLUTION: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY

The structure was published by Tiffany, K.A., Roberts, D.L., Wang, M., et al., Mohsen, A.W., Vockley, J., and Kim, J.J., in 1997 in a paper entitled "Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ISOVALERYL-COA DEHYDROGENASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ISOVALERYL-COA DEHYDROGENASE P26440 (30-423) (IVD_HUMAN)search Homo sapienssearch 93% 394 98%
B ISOVALERYL-COA DEHYDROGENASE P26440 (30-423) (IVD_HUMAN)search Homo sapienssearch 93% 394 98%
C ISOVALERYL-COA DEHYDROGENASE P26440 (30-423) (IVD_HUMAN)search Homo sapienssearch 93% 394 98%
D ISOVALERYL-COA DEHYDROGENASE P26440 (30-423) (IVD_HUMAN)search Homo sapienssearch 93% 394 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26440 (30 - 423) ISOVALERYL-COA DEHYDROGENASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P26440) Medium chain acyl-CoA dehydrogenase-like, C-terminal domainsearch, Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domainssearch Butyryl-Coa Dehydrogenase, subunit A, domain 1search, Butyryl-CoA Dehydrogenase, subunit A, domain 2search, Butyryl-CoA Dehydrogenase, subunit A, domain 3search PF00441: Acyl-CoA dehydrogenase, C-terminal domainsearch, PF02770: Acyl-CoA dehydrogenase, middle domainsearch, PF02771: Acyl-CoA dehydrogenase, N-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P26440) acyl-CoA dehydrogenase activitysearch oxidoreductase activitysearch flavin adenine dinucleotide bindingsearch oxidoreductase activity, acting on the CH-CH group of donorssearch isovaleryl-CoA dehydrogenase activitysearch mitochondrial matrixsearch mitochondrionsearch branched-chain amino acid catabolic processsearch oxidation-reduction processsearch metabolic processsearch cellular nitrogen compound metabolic processsearch leucine catabolic processsearch small molecule metabolic processsearch

Chain InterPro annotation
A, B, C, D Acyl-CoA dehydrogenase, conserved sitesearch Acyl-CoA oxidase/dehydrogenase, central domainsearch Acyl-CoA dehydrogenase/oxidase C-terminalsearch Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domainsearch Acyl-CoA dehydrogenase/oxidase, N-terminalsearch