› 1ive

X-ray diffraction
2.4Å resolution

STRUCTURES OF AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE

Released:
DOI: 10.2210/pdb1ive/pdb
PDB entry 1ive coloured by chain, front view.
PDB entry 1ive coloured by chain, side view.
PDB entry 1ive coloured by chain, top view.
Source organism: Influenza A virus (A/Tokyo/3/1967(H2N2))
Primary publication:
Structures of aromatic inhibitors of influenza virus neuraminidase.
Jedrzejas MJ, Singh S, Brouillette WJ, Laver WG, Air GM, Luo M
Biochemistry 34 3144-51 (1995)
PMID: 7880809

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 388 amino acids
Theoretical weight: 43.14 KDa
Source organism: Influenza A virus (A/Tokyo/3/1967(H2N2))
Expression system: Not provided
UniProt:
  • Canonical: P06820 (Residues: 82-469; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, NDG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
2 bound ligands:
Ligand CA 2 x CA
Ligand ST3 2 x ST3
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 121.88Å b: 140.88Å c: 141.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 not available
Expression system: Not provided

Quick links

Citations

9 review citations

Pneumococcal virulence factors: structure and function.
Jedrzejas MJ. (2001)
8 more

5 mentions without citation

Electrostatic environment of hemes in proteins: pK(a)s of hydroxyl ligands.
Song et al. (2006)
4 more