1ivb Summary

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STRUCTURES OF AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE

The structure was published by Jedrzejas, M.J., Singh, S., Brouillette, W.J., Laver, W.G., Air, G.M., and Luo, M., in 1995 in a paper entitled "Structures of aromatic inhibitors of influenza virus neuraminidase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1994.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of INFLUENZA VIRUS B/LEE/40 NEURAMINIDASE. This molecule has the UniProt identifier P03474 (NRAM_INBLE)search. The sample contained 390 residues which is < 90% of the natural sequence. Out of 390 residues 390 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INFLUENZA VIRUS B/LEE/40 NEURAMINIDASE P03474 (77-466) (NRAM_INBLE)search Influenza B virus (B/Lee/40)search < 90% 390 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03474 (77 - 466) INFLUENZA VIRUS B/LEE/40 NEURAMINIDASE Influenza B virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P03474) membranesearch virion membranesearch host cell membranesearch exo-alpha-sialidase activitysearch carbohydrate metabolic processsearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch