1itq Summary

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HUMAN RENAL DIPEPTIDASE

The structure was published by Nitanai, Y., Satow, Y., Adachi, H., and Tsujimoto, M., in 2002 in a paper entitled "Crystal Structure of Human Renal Dipeptidase Involved in beta-Lactam Hydrolysis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of RENAL DIPEPTIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RENAL DIPEPTIDASE P16444 (17-385) (DPEP1_HUMAN)search Homo sapienssearch 93% 369 100%
B RENAL DIPEPTIDASE P16444 (17-385) (DPEP1_HUMAN)search Homo sapienssearch 93% 369 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16444 (17 - 385) RENAL DIPEPTIDASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P16444) Renal dipeptidasesearch Metal-dependent hydrolasessearch PF01244: Membrane dipeptidase (Peptidase family M19)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P16444) dipeptidase activitysearch dipeptidyl-peptidase activitysearch metallodipeptidase activitysearch modified amino acid bindingsearch metallopeptidase activitysearch cysteine-type endopeptidase inhibitor activity involved in apoptotic processsearch zinc ion bindingsearch metal ion bindingsearch GPI anchor bindingsearch hydrolase activitysearch metalloexopeptidase activitysearch peptidase activitysearch protein bindingsearch proteolysissearch negative regulation of cell migrationsearch cellular response to drugsearch arachidonic acid metabolic processsearch small molecule metabolic processsearch cellular response to nitric oxidesearch cellular response to calcium ionsearch homocysteine metabolic processsearch antibiotic metabolic processsearch glutathione metabolic processsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch cellular lactam catabolic processsearch negative regulation of apoptotic processsearch leukotriene metabolic processsearch anchored component of membranesearch extracellular spacesearch plasma membranesearch cell projectionsearch extracellular vesicular exosomesearch apical part of cellsearch microvillus membranesearch membranesearch apical plasma membranesearch

Chain InterPro annotation
A, B Membrane dipeptidase, active sitesearch Renal dipeptidase familysearch Dipeptidase 1search