1is0 Summary

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Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor

The structure was published by Davidson, J.P., Lubman, O., Rose, T., Waksman, G., and Martin, S.F., in 2002 in a paper entitled "Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tyrosine-protein kinase transforming protein SRC and AY0 GLU GLU ILE peptide.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase transforming protein SRC P00524 (144-249) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 106 96%
B Tyrosine-protein kinase transforming protein SRC P00524 (144-249) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 106 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00524 (144 - 249) Tyrosine-protein kinase transforming protein SRC Rous sarcoma virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A, B SH2 domainsearch