1irk Summary

pdbe.org/1irk
spacer

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR

The structure was published by Hubbard, S.R., Wei, L., Ellis, L., and Hendrickson, W.A., in 1994 in a paper entitled "Crystal structure of the tyrosine kinase domain of the human insulin receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of INSULIN RECEPTOR TYROSINE KINASE DOMAIN. This molecule has the UniProt identifier P06213 (INSR_HUMAN)search. The sample contained 306 residues which is < 90% of the natural sequence. Out of 306 residues 298 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN RECEPTOR TYROSINE KINASE DOMAIN P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) INSULIN RECEPTOR TYROSINE KINASE DOMAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P06213) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch transmembrane receptor protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch