1irj Summary

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Crystal Structure of the MRP14 complexed with CHAPS

The structure was published by Itou, H., Yao, M., Fujita, I., et al., Suzuki, M., Nishihira, J., and Tanaka, I., in 2002 in a paper entitled "The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Migration Inhibitory Factor-Related Protein 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
B Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
C Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
D Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
E Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
F Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
G Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%
H Migration Inhibitory Factor-Related Protein 14 P06702 (2-114) (S10A9_HUMAN)search Homo sapienssearch 99% 113 75%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06702 (2 - 114) Migration Inhibitory Factor-Related Protein 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H (P06702) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D, E, F, G, H (P06702) calcium ion bindingsearch RAGE receptor bindingsearch antioxidant activitysearch protein bindingsearch zinc ion bindingsearch arachidonic acid bindingsearch microtubule bindingsearch metal ion bindingsearch signal transducer activitysearch Toll-like receptor 4 bindingsearch regulation of inflammatory responsesearch leukocyte chemotaxissearch apoptotic processsearch cell-cell signalingsearch actin cytoskeleton reorganizationsearch defense response to bacteriumsearch regulation of integrin biosynthetic processsearch defense response to fungussearch response to zinc ionsearch autophagysearch inflammatory responsesearch immune system processsearch leukocyte migration involved in inflammatory responsesearch positive regulation of intrinsic apoptotic signaling pathwaysearch signal transductionsearch response to ethanolsearch cytokine productionsearch response to lipopolysaccharidesearch positive regulation of inflammatory responsesearch chemokine productionsearch neutrophil chemotaxissearch sequestering of zinc ionsearch positive regulation of cell growthsearch neutrophil aggregationsearch positive regulation of NF-kappaB transcription factor activitysearch chemotaxissearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch chronic inflammatory responsesearch innate immune responsesearch regulation of cytoskeleton organizationsearch cytoplasmsearch extracellular spacesearch extracellular vesicular exosomesearch membranesearch plasma membranesearch cytoskeletonsearch cytosolsearch extracellular regionsearch nucleussearch

Chain InterPro annotation
A, B, C, D, E, F, G, H S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-A9search