1ir3 Summary

pdbe.org/1ir3
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PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG

The structure was published by Hubbard, S.R., in 1997 in a paper entitled "Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN RECEPTOR and PEPTIDE SUBSTRATE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN RECEPTOR P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 99%
B PEPTIDE SUBSTRATE Not available
Not available Not available 18 33%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) INSULIN RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
B

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P06213) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch ATP bindingsearch protein tyrosine kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
B