1ioh Summary

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INSULIN MUTANT A8 HIS,(B1, B10, B16, B27)GLU, DES-B30, NMR, 26 STRUCTURES

The structure was published by Olsen, H.B., Ludvigsen, S., and Kaarsholm, N.C., in 1998 in a paper entitled "The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (INSULIN PRECURSOR).

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (INSULIN PRECURSOR) P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B PROTEIN (INSULIN PRECURSOR) P01308 (25-53) (INS_HUMAN)search Homo sapienssearch 100% 29 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) PROTEIN (INSULIN PRECURSOR) Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
B (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P01308) hormone activitysearch extracellular regionsearch
B (P01308) hormone activitysearch extracellular regionsearch

Chain InterPro annotation
A Insulin-likesearch Insulin, conserved sitesearch
B Insulin-likesearch