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GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (GRB2) C-TERMINAL SH3 DOMAIN COMPLEXED WITH A LIGAND PEPTIDE (NMR, MINIMIZED MEAN STRUCTURE)

Solution NMR
PDB entry 1io6 coloured by chain, front view.
PDB entry 1io6 coloured by chain, side view.
PDB entry 1io6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Growth factor receptor-bound protein 2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 4378.04 Å2
Buried surface area: 1081.72 Å2
Dissociation area: 540.86 Å2
Dissociation energy (ΔGdiss): 1.77 kcal/mol
Dissociation entropy (TΔSdiss): 7.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158855

Macromolecules

Growth factor receptor-bound protein 2
Chain: A
Length: 59 amino acids
Theoretical weight: 6.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62993 (Residues: 159-215; Coverage: 26%)
Gene names: ASH, GRB2
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Growth factor receptor-bound protein 2 in PDB entry 1io6, assembly 1, front view.
Growth factor receptor-bound protein 2 in PDB entry 1io6, assembly 1, side view.
Growth factor receptor-bound protein 2 in PDB entry 1io6, assembly 1, top view.
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A LIGAND PEPTIDE
Chain: B
Length: 10 amino acids
Theoretical weight: 1.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
A LIGAND PEPTIDE in PDB entry 1io6, assembly 1, front view.
A LIGAND PEPTIDE in PDB entry 1io6, assembly 1, side view.
A LIGAND PEPTIDE in PDB entry 1io6, assembly 1, top view.
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