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CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE AT 2.3 ANGSTROMS RESOLUTION

Source organism: Bos taurus
Biochemical function: inositol-1,3,4-trisphosphate 1-phosphatase activity
Biological process: phosphatidylinositol phosphate biosynthetic process
Cellular component: not assigned

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EC 3.1.3.57: Inositol-1,4-bisphosphate 1-phosphatase

Reaction catalysed:
1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D-myo-inositol 4-phosphate + phosphate
Systematic name:
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Alternative Name(s):
  • Inositol polyphosphate 1-phosphatase
  • Inositol-polyphosphate 1-phosphatase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00459
Domain description: Inositol monophosphatase family
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
The deposited structure of PDB entry 1inp contains 1 copy of Pfam domain PF00459 (Inositol monophosphatase family) in Inositol polyphosphate 1-phosphatase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020550
Domain description: Inositol monophosphatase, conserved site
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
IPR020583
Domain description: Inositol monophosphatase, metal-binding site
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
IPR044897
Domain description: Inositol polyphosphate 1-phosphatase, domain 1
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
IPR000760
Domain description: Inositol monophosphatase-like
Occurring in:
  1. Inositol polyphosphate 1-phosphatase

Structure domains

CATH CATH domains
3.30.540.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Fructose-1,6-Bisphosphatase; Chain A, domain 1
Homology: Fructose-1,6-Bisphosphatase, subunit A, domain 1
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
The deposited structure of PDB entry 1inp contains 1 copy of CATH domain 3.30.540.10 (Fructose-1,6-Bisphosphatase; Chain A, domain 1) in Inositol polyphosphate 1-phosphatase. Showing 1 copy in chain A.
3.40.190.80
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: D-Maltodextrin-Binding Protein; domain 2
Homology: D-Maltodextrin-Binding Protein; domain 2
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
The deposited structure of PDB entry 1inp contains 1 copy of CATH domain 3.40.190.80 (D-Maltodextrin-Binding Protein; domain 2) in Inositol polyphosphate 1-phosphatase. Showing 1 copy in chain A.
4.10.460.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Inositol Polyphosphate 1-phosphatase; domain 1
Homology: Inositol Polyphosphate 1-phosphatase, domain 1
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
The deposited structure of PDB entry 1inp contains 1 copy of CATH domain 4.10.460.10 (Inositol Polyphosphate 1-phosphatase; domain 1) in Inositol polyphosphate 1-phosphatase. Showing 1 copy in chain A.
SCOP SCOP annotation
56656
Class: Multi-domain proteins (alpha and beta)
Fold: Carbohydrate phosphatase
Superfamily: Carbohydrate phosphatase
Occurring in:
  1. Inositol polyphosphate 1-phosphatase
The deposited structure of PDB entry 1inp contains 1 copy of SCOP domain 56656 (Inositol monophosphatase/fructose-1,6-bisphosphatase-like) in Inositol polyphosphate 1-phosphatase. Showing 1 copy in chain A.

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