1ing Summary

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INFLUENZA A SUBTYPE N2 NEURAMINIDASE COMPLEXED WITH AROMATIC BANA109 INHIBITOR

The structure was published by Singh, S., Jedrzejas, M.J., Air, G.M., Luo, M., Laver, W.G., and Brouillette, W.J., in 1995 in a paper entitled "Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1995.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INFLUENZA A SUBTYPE N2 NEURAMINIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INFLUENZA A SUBTYPE N2 NEURAMINIDASE P06820 (82-469) (NRAM_I67A0)search Influenza A virus (A/Tokyo/3/1967(H2N2))search < 90% 388 100%
B INFLUENZA A SUBTYPE N2 NEURAMINIDASE P06820 (82-469) (NRAM_I67A0)search Influenza A virus (A/Tokyo/3/1967(H2N2))search < 90% 388 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06820 (82 - 469) INFLUENZA A SUBTYPE N2 NEURAMINIDASE Influenza A virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P06820) membranesearch virion membranesearch host cell membranesearch exo-alpha-sialidase activitysearch carbohydrate metabolic processsearch

Chain InterPro annotation
A, B Glycoside hydrolase, family 34search Sialidasessearch