1ilg Summary


Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain

The structure was published by Watkins, R.E., Wisely, G.B., Moore, L.B., et al., Willson, T.M., Kliewer, S.A., and Redinbo, M.R., in 2001 in a paper entitled "The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.52 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ORPHAN NUCLEAR RECEPTOR PXR. This molecule has the UniProt identifier O75469 (NR1I2_HUMAN)search. The sample contained 316 residues which is < 90% of the natural sequence. Out of 316 residues 263 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ORPHAN NUCLEAR RECEPTOR PXR O75469 (130-434) (NR1I2_HUMAN)search Homo sapienssearch < 90% 316 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75469 (130 - 434) ORPHAN NUCLEAR RECEPTOR PXR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (O75469) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch thyroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch