1il6 Summary

pdbe.org/1il6
spacer

HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE

The structure was published by Xu, G.Y., Yu, H.A., Hong, J., et al., McDonagh, T., Kay, L.E., and Cumming, D.A., in 1997 in a paper entitled "Solution structure of recombinant human interleukin-6." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of INTERLEUKIN-6. This molecule has the UniProt identifier P05231 (IL6_HUMAN)search. The sample contained 185 residues which is < 90% of the natural sequence. Out of 185 residues 166 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERLEUKIN-6 P05231 (28-212) (IL6_HUMAN)search Homo sapienssearch 91% 185 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05231 (28 - 212) INTERLEUKIN-6 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P05231) Long-chain cytokinessearch Growth Hormone; Chain: A;search PF00489: Interleukin-6/G-CSF/MGF familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P05231) cytokine activitysearch interleukin-6 receptor bindingsearch extracellular regionsearch immune responsesearch

Chain InterPro annotation
A Interleukin-6/Interleukin-23/GCSF/MGFsearch Interleukin-6search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch