1ik0 Summary

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Solution Structure of Human IL-13

The structure was published by Moy, F.J., Diblasio, E., Wilhelm, J., and Powers, R., in 2001 in a paper entitled "Solution structure of human IL-13 and implication for receptor binding." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of INTERLEUKIN-13. This molecule has the UniProt identifier P35225 (IL13_HUMAN)search. The sample contained 113 residues which is 92% of the natural sequence. Out of 113 residues 113 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERLEUKIN-13 P35225 (35-146) (IL13_HUMAN)search Homo sapienssearch 92% 113 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35225 (35 - 146) INTERLEUKIN-13 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P35225) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF03487: Interleukin-13search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P35225) extracellular regionsearch extracellular spacesearch cytoplasmsearch external side of plasma membranesearch cytokine receptor bindingsearch interleukin-13 receptor bindingsearch cytokine activitysearch protein bindingsearch inflammatory responsesearch positive regulation of protein secretionsearch negative regulation of transforming growth factor beta productionsearch immune responsesearch response to ethanolsearch response to nicotinesearch positive regulation of tyrosine phosphorylation of Stat6 proteinsearch positive regulation of smooth muscle cell proliferationsearch response to mechanical stimulussearch cellular response to mechanical stimulussearch positive regulation of B cell proliferationsearch positive regulation of macrophage activationsearch positive regulation of pancreatic stellate cell proliferationsearch positive regulation of lung goblet cell differentiationsearch cell-cell signalingsearch positive regulation of connective tissue growth factor productionsearch positive regulation of release of sequestered calcium ion into cytosolsearch regulation of proton transportsearch response to lipopolysaccharidesearch signal transductionsearch cellular response to cytokine stimulussearch positive regulation of ion transportsearch negative regulation of lung ciliated cell differentiationsearch positive regulation of immunoglobulin productionsearch cellular component movementsearch

Chain InterPro annotation
A Interleukin-4/interleukin-13search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch Interleukin-4/interleukin-13, conserved sitesearch Interleukin-13search