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CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF SECRETED FRIZZLED-RELATED PROTEIN 3 (SFRP-3;FZB)

X-ray diffraction
1.9Å resolution
PDB entry 1ijx coloured by chain, front view.
PDB entry 1ijx coloured by chain, side view.
PDB entry 1ijx coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Secreted frizzled-related protein 3
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Multimeric state: homo dimer
Accessible surface area: 13108.77 Å2
Buried surface area: 2526.47 Å2
Dissociation area: 1,177.84 Å2
Dissociation energy (ΔGdiss): 15.51 kcal/mol
Dissociation entropy (TΔSdiss): 11.72 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161300
Assembly 2
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Assembly Name: Secreted frizzled-related protein 3
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Multimeric state: homo dimer
Accessible surface area: 12377.21 Å2
Buried surface area: 2293.95 Å2
Dissociation area: 1,146.97 Å2
Dissociation energy (ΔGdiss): 16.46 kcal/mol
Dissociation entropy (TΔSdiss): 11.6 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161300
Assembly 3
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Assembly Name: Secreted frizzled-related protein 3
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Multimeric state: homo dimer
Accessible surface area: 12562.7 Å2
Buried surface area: 2434.77 Å2
Dissociation area: 1,217.38 Å2
Dissociation energy (ΔGdiss): 18.59 kcal/mol
Dissociation entropy (TΔSdiss): 11.66 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-161300

Macromolecules

Secreted frizzled-related protein 3
Chains: A, B, C, D, E, F
Length: 127 amino acids
Theoretical weight: 14.2 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P97401 (Residues: 33-157; Coverage: 43%)
Gene names: Fiz, Fre, Frzb, Frzb1, Sfrp3
Pfam: Fz domain
InterPro:
CATH: Frizzled cysteine-rich domain
SCOP: Frizzled cysteine-rich domain
Secreted frizzled-related protein 3 in PDB entry 1ijx, assembly 1, front view.
Secreted frizzled-related protein 3 in PDB entry 1ijx, assembly 1, side view.
Secreted frizzled-related protein 3 in PDB entry 1ijx, assembly 1, top view.
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