1ijr Summary


Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic

The structure was published by Kawahata, N., Yang, M.G., Luke, G.P., et al., Eyermann, C.J., Bohacek, R.S., and Sawyer, T.K., in 2001 in a paper entitled "A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK. This molecule has the UniProt identifier P06239 (LCK_HUMAN)search. The sample contained 104 residues which is < 90% of the natural sequence. Out of 104 residues 104 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK P06239 (124-226) (LCK_HUMAN)search Homo sapienssearch < 90% 104 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A SH2 domainsearch