› 1ijq

X-ray diffraction
1.5Å resolution

Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair

Released:
DOI: 10.2210/pdb1ijq/pdb
PDB entry 1ijq coloured by chain, front view.
PDB entry 1ijq coloured by chain, side view.
PDB entry 1ijq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC
Nat Struct Biol 8 499-504 (2001)
PMID: 11373616

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 316 amino acids
Theoretical weight: 35.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01130 (Residues: 398-713; Coverage: 38%)
Gene name: LDLR
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P3221
Unit cell:
a: 76.284Å b: 76.284Å c: 265.445Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.25
Expression system: Cricetulus griseus

Quick links

Citations

31 review citations

Wnt signaling in osteoblasts and bone diseases.
Westendorf et al. (2004)
30 more

18 mentions without citation

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
Little et al. (2002)
17 more