1iip Summary

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Bovine Cyclophilin 40, Tetragonal Form

The structure was published by Taylor, P., Dornan, J., Carrello, A., Minchin, R.F., Ratajczak, T., and Walkinshaw, M.D., in 2001 in a paper entitled "Two structures of cyclophilin 40: folding and fidelity in the TPR domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Cyclophilin 40. This molecule has the UniProt identifier P26882 (PPID_BOVIN)search. The sample contained 370 residues which is 100% of the natural sequence. Out of 370 residues 297 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cyclophilin 40 P26882 (1-370) (PPID_BOVIN)search Bos taurussearch 100% 370 80%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26882 (1 - 370) Cyclophilin 40 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P26882) Tetratricopeptide repeat (TPR)search, Cyclophilin (peptidylprolyl isomerase)search Cyclophilin-likesearch, DNA polymerase; domain 1search PF00160: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch, PF13414: TPR repeatsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P26882) peptidyl-prolyl cis-trans isomerase activitysearch heat shock protein bindingsearch protein bindingsearch Hsp70 protein bindingsearch isomerase activitysearch Hsp90 protein bindingsearch transcription factor bindingsearch estrogen receptor bindingsearch peptide bindingsearch protein peptidyl-prolyl isomerizationsearch protein foldingsearch chaperone-mediated protein foldingsearch protein complex assemblysearch lipid particle organizationsearch cellular response to UV-Asearch positive regulation of viral genome replicationsearch positive regulation of apoptotic processsearch negative regulation of transcription from RNA polymerase II promotersearch transportsearch apoptotic processsearch positive regulation of protein secretionsearch protein transportsearch cytoplasmsearch nucleussearch nucleolussearch

Chain InterPro annotation
A Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Tetratricopeptide-like helical domainsearch Tetratricopeptide repeat-containing domainsearch Tetratricopeptide repeatsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-like domainsearch