1ihb Summary

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CRYSTAL STRUCTURE OF P18-INK4C(INK6)

The structure was published by Venkataramani, R., Swaminathan, K., and Marmorstein, R., in 1998 in a paper entitled "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLIN-DEPENDENT KINASE 6 INHIBITOR.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 6 INHIBITOR P42773 (1-162) (CDN2C_HUMAN)search Homo sapienssearch 96% 162 96%
B CYCLIN-DEPENDENT KINASE 6 INHIBITOR P42773 (1-162) (CDN2C_HUMAN)search Homo sapienssearch 96% 162 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42773 (1 - 162) CYCLIN-DEPENDENT KINASE 6 INHIBITOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P42773) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P42773) oligodendrocyte differentiationsearch mitotic cell cyclesearch negative regulation of phosphorylationsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch cell cyclesearch negative regulation of cell proliferationsearch negative regulation of cell growthsearch cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch negative regulation of protein serine/threonine kinase activitysearch protein bindingsearch protein kinase bindingsearch cyclin-dependent protein serine/threonine kinase inhibitor activitysearch cytoplasmsearch cytosolsearch nucleussearch

Chain InterPro annotation
A, B Ankyrin repeatsearch Ankyrin repeat-containing domainsearch