1ih0 Summary


Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033

The structure was published by Wang, X., Li, M.X., Spyracopoulos, L., et al., Chandra, M., Solaro, R.J., and Sykes, B.D., in 2001 in a paper entitled "Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES. This molecule has the UniProt identifier P63316 (TNNC1_HUMAN)search. The sample contained 71 residues which is < 90% of the natural sequence. Out of 71 residues 71 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES P63316 (91-161) (TNNC1_HUMAN)search Homo sapienssearch 100% 71 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63316) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch

Chain ID Molecular function (GO)
A (P63316) calcium ion bindingsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch