› 1ih0

Solution NMR

Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033

Released:
DOI: 10.2210/pdb1ih0/pdb
PDB entry 1ih0 coloured by chain, ensemble of 30 models, front view.
PDB entry 1ih0 coloured by chain, ensemble of 30 models, side view.
PDB entry 1ih0 coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.
Wang X, Li MX, Spyracopoulos L, Beier N, Chandra M, Solaro RJ, Sykes BD
J Biol Chem 276 25456-66 (2001)
PMID: 11320096

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 91-161; Coverage: 44%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand EMD 1 x EMD
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Mechanisms and use of calcium-sensitizing agents in the failing heart.
Kass et al. (2006)
11 more

4 mentions without citation

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs.
Li et al. (2015)
3 more