1igz Summary


Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

The structure was published by Malkowski, M.G., Thuresson, E.D., Lakkides, K.M., et al., Micielli, R., Smith, W.L., and Garavito, R.M., in 2001 in a paper entitled "Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Prostaglandin Endoperoxide H Synthase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin Endoperoxide H Synthase-1 P05979 (25-600) (PGH1_SHEEP)search Ovis ariessearch 96% 576 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (25 - 600) Prostaglandin Endoperoxide H Synthase-1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P05979) heme bindingsearch prostaglandin-endoperoxide synthase activitysearch peroxidase activitysearch metal ion bindingsearch oxidoreductase activitysearch dioxygenase activitysearch prostaglandin biosynthetic processsearch inflammatory responsesearch oxidation-reduction processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch fatty acid biosynthetic processsearch regulation of blood pressuresearch lipid metabolic processsearch cyclooxygenase pathwaysearch response to oxidative stresssearch intracellular membrane-bounded organellesearch integral component of membranesearch endoplasmic reticulum membranesearch nucleussearch endoplasmic reticulumsearch cytoplasmsearch organelle membranesearch membranesearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search