1igz Summary

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Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

The structure was published by Malkowski, M.G., Thuresson, E.D., Lakkides, K.M., et al., Micielli, R., Smith, W.L., and Garavito, R.M., in 2001 in a paper entitled "Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Prostaglandin Endoperoxide H Synthase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin Endoperoxide H Synthase-1 P05979 (25-600) (PGH1_SHEEP)search Ovis ariessearch 96% 576 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (25 - 600) Prostaglandin Endoperoxide H Synthase-1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P05979) prostaglandin biosynthetic processsearch oxidation-reduction processsearch cyclooxygenase pathwaysearch regulation of blood pressuresearch inflammatory responsesearch fatty acid metabolic processsearch prostaglandin metabolic processsearch response to oxidative stresssearch lipid metabolic processsearch fatty acid biosynthetic processsearch peroxidase activitysearch metal ion bindingsearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch dioxygenase activitysearch oxidoreductase activitysearch integral component of membranesearch intracellular membrane-bounded organellesearch organelle membranesearch membranesearch endoplasmic reticulumsearch nucleussearch endoplasmic reticulum membranesearch cytoplasmsearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search