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INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS AT 2.0 A RESOLUTION

The structure was published by Hennig, M., Darimont, B., Sterner, R., Kirschner, K., and Jansonius, J.N., in 1995 in a paper entitled "2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE. This molecule has the UniProt identifier Q06121 (TRPC_SULSO)search. The sample contained 248 residues which is 100% of the natural sequence. Out of 248 residues 247 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE Q06121 (1-248) (TRPC_SULSO)search Sulfolobus solfataricus P2search 90% 248 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q06121 (1 - 248) INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE Sulfolobus solfataricus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q06121) Tryptophan biosynthesis enzymessearch Aldolase class Isearch PF00218: Indole-3-glycerol phosphate synthasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q06121) indole-3-glycerol-phosphate synthase activitysearch catalytic activitysearch lyase activitysearch carboxy-lyase activitysearch aromatic amino acid family biosynthetic processsearch tryptophan metabolic processsearch metabolic processsearch tryptophan biosynthetic processsearch cellular amino acid biosynthetic processsearch

Chain InterPro annotation
A Indole-3-glycerol phosphate synthase, conserved sitesearch Ribulose-phosphate binding barrelsearch Aldolase-type TIM barrelsearch Indole-3-glycerol phosphate synthasesearch