1ig8 Summary


Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence

The structure was published by Kuser, P.R., Krauchenco, S., Antunes, O.A., and Polikarpov, I., in 2000 in a paper entitled "The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of hexokinase PII. This molecule has the UniProt identifier P04807 (HXKB_YEAST)search. The sample contained 486 residues which is 100% of the natural sequence. Out of 486 residues 469 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A hexokinase PII P04807 (1-486) (HXKB_YEAST)search Saccharomyces cerevisiae S288csearch 100% 486 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04807 (1 - 486) hexokinase PII Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P04807) Hexokinasesearch Nucleotidyltransferase; domain 5search, Hexokinase; domain 1search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P04807) ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch nucleotide bindingsearch transferase activitysearch kinase activitysearch catalytic activitysearch carbohydrate metabolic processsearch glycolytic processsearch phosphorylationsearch fructose importsearch glucose importsearch carbohydrate phosphorylationsearch fructose metabolic processsearch metabolic processsearch replicative cell agingsearch mannose metabolic processsearch glucose metabolic processsearch regulation of transcription by glucosesearch hexose metabolic processsearch nucleussearch cytosolsearch mitochondrionsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch