1if6 Summary


Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide

A publication describing this structure is not available. The depositing authors are Kim, C.-Y.search; Christianson, D.W.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.09 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Carbonic Anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 99% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic Anhydrase II P00918 (2-259) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 259) Carbonic Anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch secretionsearch regulation of chloride transportsearch one-carbon metabolic processsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch response to pHsearch regulation of intracellular pHsearch response to estrogensearch response to steroid hormonesearch response to zinc ionsearch regulation of anion transportsearch response to organic substancesearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch angiotensin-activated signaling pathwaysearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch extracellular vesicular exosomesearch plasma membranesearch cytosolsearch basolateral plasma membranesearch cytoplasmsearch membranesearch microvillussearch apical part of cellsearch myelin sheathsearch axonsearch extracellular spacesearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch