› 1ien

Solution NMR

SOLUTION STRUCTURE OF TIA

Released:
DOI: 10.2210/pdb1ien/pdb
PDB entry 1ien coloured by chain, ensemble of 20 models, front view.
PDB entry 1ien coloured by chain, ensemble of 20 models, side view.
PDB entry 1ien coloured by chain, ensemble of 20 models, top view.
Source organism: Conus tulipa
Primary publication:
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.
Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ
Nat Neurosci 4 902-7 (2001)
PMID: 11528421

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157731 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho-conotoxin TIA Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.4 KDa
Source organism: Conus tulipa
Expression system: Not provided
UniProt:
  • Canonical: P58811 (Residues: 39-57; Coverage: 45%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

37 review citations

Conus venoms: a rich source of novel ion channel-targeted peptides.
Terlau et al. (2004)
36 more

4 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
3 more