1icf Summary

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CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L

The structure was published by Guncar, G., Pungercic, G., Klemencic, I., Turk, V., and Turk, D., in 1999 in a paper entitled "Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely PROTEIN (CATHEPSIN L: HEAVY CHAIN), PROTEIN (CATHEPSIN L: LIGHT CHAIN), and PROTEIN (INVARIANT CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CATHEPSIN L: HEAVY CHAIN) P07711 (114-288) (CATL1_HUMAN)search Homo sapienssearch 99% 175 100%
C PROTEIN (CATHEPSIN L: HEAVY CHAIN) P07711 (114-288) (CATL1_HUMAN)search Homo sapienssearch 99% 175 100%
B PROTEIN (CATHEPSIN L: LIGHT CHAIN) P07711 (292-333) (CATL1_HUMAN)search Homo sapienssearch 99% 42 100%
D PROTEIN (CATHEPSIN L: LIGHT CHAIN) P07711 (292-333) (CATL1_HUMAN)search Homo sapienssearch 99% 42 100%
I PROTEIN (INVARIANT CHAIN) P04233 (210-274) (HG2A_HUMAN)search Homo sapienssearch < 90% 65 100%
J PROTEIN (INVARIANT CHAIN) P04233 (210-274) (HG2A_HUMAN)search Homo sapienssearch < 90% 65 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P07711 (114 - 288) PROTEIN (CATHEPSIN L: HEAVY CHAIN) Homo sapiens
P04233 (210 - 274) PROTEIN (INVARIANT CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P07711) Papain-likesearch Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch
B, D (P07711) Papain-likesearch Cysteine proteinases. Chain Csearch PF00112: Papain family cysteine proteasesearch
I, J Thyroglobulin type-1 domainsearch Invariant Chain; Chain Isearch Thyroglobulin type-1 repeatsearch

Chain ID Molecular function (GO) Biological process (GO)
A, C (P07711) cysteine-type peptidase activitysearch proteolysissearch
B, D (P07711) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A, C Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch
B, D Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, asparagine active sitesearch
I, J Thyroglobulin type-1search MHC class II-associated invariant chainsearch