1ic8 Summary

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HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT

The structure was published by Chi, Y-.I., Frantz, J.D., Oh, B-.C., Hansen, L., Dhe-Paganon, S., and Shoelson, S.E., in 2002 in a paper entitled "Diabetes mutations delineate an atypical POU domains in HNF1-Alpha" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', and HEPATOCYTE NUCLEAR FACTOR 1-ALPHA.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEPATOCYTE NUCLEAR FACTOR 1-ALPHA P20823 (85-278) (HNF1A_HUMAN)search Homo sapienssearch < 90% 194 89%
B HEPATOCYTE NUCLEAR FACTOR 1-ALPHA P20823 (85-278) (HNF1A_HUMAN)search Homo sapienssearch < 90% 194 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P20823 (85 - 278) HEPATOCYTE NUCLEAR FACTOR 1-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Homeodomainsearch, POU-specific domainsearch lambda repressor-like DNA-binding domainssearch, Homeodomain-likesearch Homeobox domainsearch, Hepatocyte nuclear factor 1 (HNF-1), N terminussearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P20823) DNA bindingsearch positive regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B Homeobox domainsearch Hepatocyte nuclear factor 1, N-terminalsearch Homeodomain-likesearch Lambda repressor-like, DNA-binding domainsearch