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HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT

X-ray diffraction
2.6Å resolution
PDB entry 1ic8 coloured by chain, front view.
PDB entry 1ic8 coloured by chain, side view.
PDB entry 1ic8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hepatocyte nuclear factor 1-alpha and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 24808.23 Å2
Buried surface area: 7473.93 Å2
Dissociation area: 1,539.82 Å2
Dissociation energy (ΔGdiss): 17.08 kcal/mol
Dissociation entropy (TΔSdiss): 12.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113950

Macromolecules

Hepatocyte nuclear factor 1-alpha
Chains: A, B
Length: 194 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20823 (Residues: 85-278; Coverage: 31%)
Gene names: HNF1A, TCF1
Pfam: Hepatocyte nuclear factor 1 (HNF-1), N terminus
InterPro:
CATH:
SCOP:
Hepatocyte nuclear factor 1-alpha in PDB entry 1ic8, assembly 1, front view.
Hepatocyte nuclear factor 1-alpha in PDB entry 1ic8, assembly 1, side view.
Hepatocyte nuclear factor 1-alpha in PDB entry 1ic8, assembly 1, top view.
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DNA chain E
Name: 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3'
Representative chains: E
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.42 KDa
5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3' in PDB entry 1ic8, assembly 1, front view.
5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3' in PDB entry 1ic8, assembly 1, side view.
5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3' in PDB entry 1ic8, assembly 1, top view.
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DNA chain F
Name: 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3'
Representative chains: F
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.46 KDa
5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3' in PDB entry 1ic8, assembly 1, front view.
5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3' in PDB entry 1ic8, assembly 1, side view.
5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3' in PDB entry 1ic8, assembly 1, top view.
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