1ias Summary

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CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12

The structure was published by Huse, M., Muir, T.W., Xu, L., Chen, Y.G., Kuriyan, J., and Massague, J., in 2001 in a paper entitled "The TGF beta receptor activation process: an inhibitor- to substrate-binding switch." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TGF-BETA RECEPTOR TYPE I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homopentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TGF-BETA RECEPTOR TYPE I P36897 (162-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 342 96%
B TGF-BETA RECEPTOR TYPE I P36897 (162-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 342 96%
C TGF-BETA RECEPTOR TYPE I P36897 (162-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 342 96%
D TGF-BETA RECEPTOR TYPE I P36897 (162-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 342 96%
E TGF-BETA RECEPTOR TYPE I P36897 (162-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 342 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P36897 (162 - 503) TGF-BETA RECEPTOR TYPE I Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Transforming growth factor beta type I GS-motifsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E (P36897) protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch transmembrane receptor protein serine/threonine kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch receptor signaling protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch membranesearch

Chain InterPro annotation
A, B, C, D, E Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch TGF beta receptor, GS motifsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch