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HUMAN P38 MAP KINASE INHIBITOR COMPLEX

The structure was published by Tong, L., Pav, S., White, D.M., et al., Cywin, C.L., Brown, M.L., and Pargellis, C.A., in 1997 in a paper entitled "A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of P38 MAP KINASE. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 43 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P38 MAP KINASE Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) P38 MAP KINASE Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch kinase activitysearch MAP kinase kinase activitysearch transferase activitysearch protein phosphorylationsearch signal transduction in response to DNA damagesearch Ras protein signal transductionsearch vascular endothelial growth factor receptor signaling pathwaysearch osteoclast differentiationsearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch angiogenesissearch positive regulation of myoblast differentiationsearch phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch gene expressionsearch activation of MAPK activitysearch positive regulation of muscle cell differentiationsearch stress-induced premature senescencesearch fatty acid oxidationsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of erythrocyte differentiationsearch skeletal muscle tissue developmentsearch striated muscle cell differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch regulation of transcription, DNA-templatedsearch toll-like receptor 2 signaling pathwaysearch positive regulation of myotube differentiationsearch cellular response to ionizing radiationsearch innate immune responsesearch muscle cell differentiationsearch toll-like receptor 9 signaling pathwaysearch response to stresssearch intracellular signal transductionsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myoblast fusionsearch signal transductionsearch DNA damage checkpointsearch mRNA metabolic processsearch glucose metabolic processsearch response to muramyl dipeptidesearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch chemotaxissearch cell surface receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch apoptotic processsearch platelet activationsearch transcription, DNA-templatedsearch positive regulation of transcription from RNA polymerase II promotersearch peptidyl-serine phosphorylationsearch regulation of sequence-specific DNA binding transcription factor activitysearch cellular response to vascular endothelial growth factor stimulussearch cellular component movementsearch stress-activated MAPK cascadesearch toll-like receptor 10 signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of protein import into nucleussearch RNA metabolic processsearch cell morphogenesissearch toll-like receptor 5 signaling pathwaysearch cellular response to DNA damage stimulussearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch cellular response to lipopolysaccharidesearch lipopolysaccharide-mediated signaling pathwaysearch response to lipopolysaccharidesearch cartilage condensationsearch neurotrophin TRK receptor signaling pathwaysearch blood coagulationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch chondrocyte differentiationsearch nucleoplasmsearch cytosolsearch nucleussearch cellsearch cytoplasmsearch spindle polesearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch