1ia8 Summary

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THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1

The structure was published by Chen, P., Luo, C., Deng, Y., et al., Lundgren, K., Kan, C.C., and O'Connor, P.M., in 2000 in a paper entitled "The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CHK1 CHECKPOINT KINASE. This molecule has the UniProt identifier O14757 (CHK1_HUMAN)search. The sample contained 289 residues which is < 90% of the natural sequence. Out of 289 residues 269 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CHK1 CHECKPOINT KINASE O14757 (1-289) (CHK1_HUMAN)search Homo sapienssearch < 90% 289 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14757 (1 - 289) CHK1 CHECKPOINT KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14757) transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch