1i9o Summary

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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE

The structure was published by Kim, C.Y., Chandra, P.P., Jain, A., and Christianson, D.W., in 2001 in a paper entitled "Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.86 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch one-carbon metabolic processsearch bicarbonate transportsearch odontogenesis of dentin-containing toothsearch response to steroid hormonesearch secretionsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch carbon dioxide transportsearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch kidney developmentsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch response to organic substancesearch response to estrogensearch morphogenesis of an epitheliumsearch cytoplasmsearch cytosolsearch axonsearch plasma membranesearch extracellular vesicular exosomesearch apical part of cellsearch basolateral plasma membranesearch extracellular spacesearch microvillussearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch