1i9n Summary



The structure was published by Kim, C.Y., Chandra, P.P., Jain, A., and Christianson, D.W., in 2001 in a paper entitled "Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.86 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytosolsearch apical part of cellsearch myelin sheathsearch cytoplasmsearch plasma membranesearch membranesearch extracellular spacesearch extracellular vesicular exosomesearch axonsearch basolateral plasma membranesearch microvillussearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch zinc ion bindingsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch cellular response to fluid shear stresssearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch bicarbonate transportsearch regulation of intracellular pHsearch regulation of anion transportsearch response to zinc ionsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch response to pHsearch secretionsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch one-carbon metabolic processsearch response to organic substancesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch