1i9a Summary

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STRUCTURAL STUDIES OF CHOLESTEROL BIOSYNTHESIS: MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE AND ISOPENTENYL DIPHOSPHATE ISOMERASE

The structure was published by Bonanno, J.B., Edo, C., Eswar, N., et al., Studier, F.W., Sali, A., and Burley, S.K., in 2001 in a paper entitled "Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE Q46822 (1-182) (IDI_ECOLI)search Escherichia coli K-12search 100% 182 97%
B ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE Q46822 (1-182) (IDI_ECOLI)search Escherichia coli K-12search 100% 182 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q46822 (1 - 182) ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q46822) IPP isomerase-likesearch Nucleoside Triphosphate Pyrophosphohydrolasesearch PF00293: NUDIX domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q46822) hydrolase activitysearch isopentenyl-diphosphate delta-isomerase activitysearch isomerase activitysearch metal ion bindingsearch isoprenoid biosynthetic processsearch ubiquinone biosynthetic processsearch dimethylallyl diphosphate biosynthetic processsearch cellular response to DNA damage stimulussearch cytoplasmsearch

Chain InterPro annotation
A, B NUDIX hydrolase domainsearch Isopentenyl-diphosphate delta-isomerase, type 1search NUDIX hydrolase domain-likesearch