1i90 Summary

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CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)

The structure was published by Kim, C.Y., Whittington, D.A., Chang, J.S., Liao, J., May, J.A., and Christianson, D.W., in 2002 in a paper entitled "Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch bicarbonate transportsearch response to steroid hormonesearch positive regulation of bone resorptionsearch response to estrogensearch angiotensin-activated signaling pathwaysearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch response to zinc ionsearch secretionsearch odontogenesis of dentin-containing toothsearch carbon dioxide transportsearch regulation of anion transportsearch response to organic substancesearch response to pHsearch kidney developmentsearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch extracellular spacesearch cytosolsearch plasma membranesearch cytoplasmsearch microvillussearch extracellular vesicular exosomesearch apical part of cellsearch axonsearch basolateral plasma membranesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch