1i44 Summary

pdbe.org/1i44
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CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE

The structure was published by Till, J.H., Ablooglu, A.J., Frankel, M., Bishop, S.M., Kohanski, R.A., and Hubbard, S.R., in 2001 in a paper entitled "Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of INSULIN RECEPTOR. This molecule has the UniProt identifier P06213 (INSR_HUMAN)search. The sample contained 306 residues which is < 90% of the natural sequence. Out of 306 residues 278 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN RECEPTOR P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) INSULIN RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P06213) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch transmembrane receptor protein tyrosine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch