1i1i Summary



The structure was published by Brown, C.K., Madauss, K., Lian, W., Beck, M.R., Tolbert, W.D., and Rodgers, D.W., in 2001 in a paper entitled "Structure of neurolysin reveals a deep channel that limits substrate access." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of NEUROLYSIN. This molecule has the UniProt identifier P42676 (NEUL_RAT)search. The sample contained 681 residues which is 97% of the natural sequence. Out of 681 residues 665 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
P NEUROLYSIN P42676 (24-704) (NEUL_RAT)search Rattus norvegicussearch 96% 681 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42676 (24 - 704) NEUROLYSIN Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
P (P42676) Neurolysin-likesearch Endopeptidase. Chain P; domain 1search, Collagenase (Catalytic Domain)search, Neurolysin, domain 3search PF01432: Peptidase family M3search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
P (P42676) metalloendopeptidase activitysearch peptidase activitysearch metallopeptidase activitysearch hydrolase activitysearch peptide bindingsearch metal ion bindingsearch cytoplasmsearch mitochondrionsearch plasma membranesearch proteolysissearch

Chain InterPro annotation
P Peptidase M3A/M3Bsearch Neurolysin/Thimet oligopeptidase, domain 2search Metallopeptidase, catalytic domainsearch Neurolysin/Thimet oligopeptidase, N-terminalsearch