1i0z Summary



The structure was published by Read, J.A., Winter, V.J., Eszes, C.M., Sessions, R.B., and Brady, R.L., in 2001 in a paper entitled "Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of L-LACTATE DEHYDROGENASE H CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A L-LACTATE DEHYDROGENASE H CHAIN P07195 (2-334) (LDHB_HUMAN)search Homo sapienssearch 99% 333 99%
B L-LACTATE DEHYDROGENASE H CHAIN P07195 (2-334) (LDHB_HUMAN)search Homo sapienssearch 99% 333 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07195 (2 - 334) L-LACTATE DEHYDROGENASE H CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P07195) LDH N-terminal domain-likesearch, Lactate & malate dehydrogenases, C-terminal domainsearch NAD(P)-binding Rossmann-like Domainsearch, L-2-Hydroxyisocaproate Dehydrogenase, subunit A, domain 2search PF00056: lactate/malate dehydrogenase, NAD binding domainsearch, PF02866: lactate/malate dehydrogenase, alpha/beta C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P07195) cellular carbohydrate metabolic processsearch oxidation-reduction processsearch carbohydrate metabolic processsearch cellular metabolic processsearch small molecule metabolic processsearch pyruvate metabolic processsearch lactate metabolic processsearch NAD metabolic processsearch L-lactate dehydrogenase activitysearch identical protein bindingsearch oxidoreductase activitysearch protein bindingsearch lactate dehydrogenase activitysearch kinase bindingsearch NAD bindingsearch oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorsearch catalytic activitysearch extracellular vesicular exosomesearch cytoplasmsearch membranesearch mitochondrionsearch cytosolsearch

Chain InterPro annotation
A, B Lactate/malate dehydrogenase, N-terminalsearch L-lactate/malate dehydrogenasesearch L-lactate dehydrogenasesearch Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalsearch NAD(P)-binding domainsearch L-lactate dehydrogenase, active sitesearch Lactate/malate dehydrogenase, C-terminalsearch