1i09 Summary

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STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B)

The structure was published by ter Haar, E., Coll, J.T., Austen, D.A., Hsiao, H.M., Swenson, L., and Jain, J., in 2001 in a paper entitled "Structure of GSK3beta reveals a primed phosphorylation mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of GLYCOGEN SYNTHASE KINASE-3 BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 81%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch kinase activitysearch ionotropic glutamate receptor bindingsearch tau-protein kinase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein kinase A catalytic subunit bindingsearch protein kinase bindingsearch tau protein bindingsearch p53 bindingsearch integrin bindingsearch NF-kappaB bindingsearch nucleotide bindingsearch RNA polymerase II transcription factor bindingsearch transferase activitysearch beta-catenin bindingsearch ubiquitin protein ligase bindingsearch protein phosphorylationsearch protein localization to microtubulesearch extrinsic apoptotic signaling pathway in absence of ligandsearch ER overload responsesearch myoblast fusionsearch glycogen metabolic processsearch positive regulation of apoptotic processsearch positive regulation of Rac GTPase activitysearch negative regulation of apoptotic processsearch circadian rhythmsearch negative regulation of signal transductionsearch axonogenesissearch negative regulation of dendrite morphogenesissearch Wnt signaling pathwaysearch hippocampus developmentsearch positive regulation of protein complex assemblysearch regulation of neuronal synaptic plasticitysearch epithelial to mesenchymal transitionsearch negative regulation of MAP kinase activitysearch peptidyl-serine phosphorylationsearch nervous system developmentsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch negative regulation of NFAT protein import into nucleussearch phosphatidylinositol-mediated signalingsearch Fc-epsilon receptor signaling pathwaysearch negative regulation of protein bindingsearch superior temporal gyrus developmentsearch regulation of microtubule-based processsearch fat cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to interleukin-3search negative regulation of glycogen biosynthetic processsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene expression by genetic imprintingsearch intracellular signal transductionsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of peptidyl-serine phosphorylationsearch cellular response to mechanical stimulussearch positive regulation of protein export from nucleussearch canonical Wnt signaling pathwaysearch cell migrationsearch multicellular organismal developmentsearch negative regulation of type B pancreatic cell developmentsearch establishment of cell polaritysearch innate immune responsesearch positive regulation of peptidyl-threonine phosphorylationsearch phosphorylationsearch protein export from nucleussearch positive regulation of cell-matrix adhesionsearch myotube differentiationsearch cell differentiationsearch organ morphogenesissearch negative regulation of cardiac muscle hypertrophysearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of protein bindingsearch response to lithium ionsearch establishment or maintenance of cell polaritysearch axon guidancesearch positive regulation of protein catabolic processsearch rhythmic processsearch hypermethylation of CpG islandsearch negative regulation of glycogen (starch) synthase activitysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch carbohydrate metabolic processsearch positive regulation of stem cell differentiationsearch negative regulation of neuron projection developmentsearch re-entry into mitotic cell cyclesearch negative regulation of neuron maturationsearch response to drugsearch negative regulation of protein complex assemblysearch epidermal growth factor receptor signaling pathwaysearch cytosolsearch beta-catenin destruction complexsearch protein complexsearch plasma membranesearch cytoplasmsearch nucleussearch growth conesearch dendritic shaftsearch perinuclear region of cytoplasmsearch membrane raftsearch neuronal cell bodysearch dendritic spinesearch cell bodysearch membranesearch ribonucleoprotein complexsearch centrosomesearch membrane-bounded organellesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch