1hzz Summary

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THE ASYMMETRIC COMPLEX OF THE TWO NUCLEOTIDE-BINDING COMPONENTS (DI, DIII) OF PROTON-TRANSLOCATING TRANSHYDROGENASE

The structure was published by Cotton, N.P., White, S.A., Peake, S.J., McSweeney, S., and Jackson, J.B., in 2001 in a paper entitled "The crystal structure of an asymmetric complex of the two nucleotide binding components of proton-translocating transhydrogenase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA and PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA Q2RSB2 (1-384) (PNTAA_RHORT)search Rhodospirillum rubrum ATCC 11170search 99% 384 95%
B PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA Q2RSB2 (1-384) (PNTAA_RHORT)search Rhodospirillum rubrum ATCC 11170search 99% 384 95%
C PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTB Q2RSB4 (262-464) (PNTB_RHORT)search Rhodospirillum rubrum ATCC 11170search < 90% 203 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q2RSB2 (1 - 384) PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTAA Rhodospirillum rubrum
Q2RSB4 (262 - 464) PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE SUBUNIT PNTB Rhodospirillum rubrum

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q2RSB2) Formate/glycerate dehydrogenases, NAD-domainsearch, L-alanine dehydrogenase-likesearch NAD(P)-binding Rossmann-like Domainsearch, Rossmann foldsearch PF01262: Alanine dehydrogenase/PNT, C-terminal domainsearch, PF05222: Alanine dehydrogenase/PNT, N-terminal domainsearch
C Transhydrogenase domain III (dIII)search TPP-binding domainsearch NAD(P) transhydrogenase beta subunitsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q2RSB2) oxidation-reduction processsearch proton transportsearch NADPH regenerationsearch hydrogen ion transmembrane transportsearch NAD(P)+ transhydrogenase activitysearch oxidoreductase activitysearch NAD(P)+ transhydrogenase (AB-specific) activitysearch NAD+ bindingsearch NADH bindingsearch nucleotide bindingsearch protein bindingsearch NAD(P)+ transhydrogenase (B-specific) activitysearch protein dimerization activitysearch NAD bindingsearch
C (Q2RSB4) oxidation-reduction processsearch NADP bindingsearch NAD(P)+ transhydrogenase (AB-specific) activitysearch integral component of membranesearch

Chain InterPro annotation
A, B Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domainsearch Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminalsearch Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1search Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2search NAD(P) transhydrogenase, alpha subunitsearch
C NADP transhydrogenase, beta subunitsearch DHS-like NAD/FAD-binding domainsearch