› 1hzs

X-ray diffraction
1.82Å resolution

Crystal structure of a peptide nucleic acid duplex (BT-PNA) containing a bicyclic analogue of thymine

Released:
DOI: 10.2210/pdb1hzs/pdb
PDB entry 1hzs coloured by chain, front view.
PDB entry 1hzs coloured by chain, side view.
PDB entry 1hzs coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
1,8-Naphthyridin-2(1H)-ones. Novel Bicyclic and Tricyclic Analogues of Thymine in Peptide Nucleic Acids (PNAs)
Eldrup AB, Nielsen BB, Haaima G, Rasmussen H, Kastrup JS, Christensen C, Nielsen PE
Eur. J. Org. Chem. 9 1781-1790 (2001)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113925 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
PEPTIDE NUCLEIC ACID Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 8 nucleotides
Theoretical weight: 1.73 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P21212
Unit cell:
a: 30.34Å b: 45Å c: 49.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.264
Expression system: Not provided

Quick links

Citations

2 mentions without citation

Antibacterial Peptide Nucleic Acids-Facts and Perspectives.
Wojciechowska et al. (2020)
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