1hzf Summary



The structure was published by van den Elsen, J.M., Martin, A., Wong, V., Clemenza, L., Rose, D.R., and Isenman, D.E., in 2002 in a paper entitled "X-ray crystal structure of the C4d fragment of human complement component C4." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of COMPLEMENT FACTOR C4A. This molecule has the UniProt identifier P0C0L4 (CO4A_HUMAN)search. The sample contained 367 residues which is < 90% of the natural sequence. Out of 367 residues 301 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A COMPLEMENT FACTOR C4A P0C0L4 (957-1323) (CO4A_HUMAN)search Homo sapienssearch < 90% 367 82%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0C0L4 (957 - 1323) COMPLEMENT FACTOR C4A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Complement componentssearch Glycosyltransferasesearch A-macroglobulin complement componentsearch, Alpha-macro-globulin thiol-ester bond-forming regionsearch

Chain ID Cellular component (GO)
A (P0C0L4) extracellular spacesearch

Chain InterPro annotation
A Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidsearch Alpha-macroglobulin complement componentsearch Alpha-2-macroglobulin, thiol-ester bond-formingsearch Alpha-2-macroglobulin, conserved sitesearch