› 1hzf

X-ray diffraction
2.3Å resolution

C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A

Released:
DOI: 10.2210/pdb1hzf/pdb
PDB entry 1hzf coloured by chain, front view.
PDB entry 1hzf coloured by chain, side view.
PDB entry 1hzf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of the C4d fragment of human complement component C4.
van den Elsen JM, Martin A, Wong V, Clemenza L, Rose DR, Isenman DE
J Mol Biol 322 1103-15 (2002)
PMID: 12367531

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142894 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C4d-A Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 39.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0C0L4 (Residues: 957-1323; Coverage: 21%)
Gene names: C4A, CO4, CPAMD2
Sequence domains: A-macroglobulin TED domain
Structure domains: Glycosyltransferase

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 56.51Å b: 71.43Å c: 85.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.233
Expression system: Escherichia coli BL21

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Citations

9 review citations

Antibody-mediated organ-allograft rejection.
Colvin et al. (2005)
8 more

2 mentions without citation

Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens' Infectivity?
Hardy et al. (2023)
1 more