› 1hz3

Solution NMR

ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)

Released:
DOI: 10.2210/pdb1hz3/pdb
PDB entry 1hz3 coloured by chain, ensemble of 15 models, front view.
PDB entry 1hz3 coloured by chain, ensemble of 15 models, side view.
PDB entry 1hz3 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
Zhang S, Iwata K, Lachenmann MJ, Peng JW, Li S, Stimson ER, Lu Y, Felix AM, Maggio JE, Lee JP
J Struct Biol 130 130-41 (2000)
PMID: 10940221

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(42) Chain: A
Molecule details ›
Chain: A
Length: 26 amino acids
Theoretical weight: 2.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 681-706; Coverage: 4%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, and restrained molecular dynamics
Expression system: Not provided

Quick links

Citations

16 review citations

Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.
Nasica-Labouze et al. (2015)
15 more

19 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
18 more