1hyo Summary

pdbe.org/1hyo
spacer

CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH 4-(HYDROXYMETHYLPHOSPHINOYL)-3-OXO-BUTANOIC ACID

The structure was published by Bateman, R.L., Bhanumoorthy, P., Witte, J.F., McClard, R.W., Grompe, M., and Timm, D.E., in 2001 in a paper entitled "Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.3 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of FUMARYLACETOACETATE HYDROLASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FUMARYLACETOACETATE HYDROLASE P35505 (1-419) (FAAA_MOUSE)search Mus musculussearch 100% 421 99%
B FUMARYLACETOACETATE HYDROLASE P35505 (1-419) (FAAA_MOUSE)search Mus musculussearch 100% 421 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35505 (1 - 419) FUMARYLACETOACETATE HYDROLASE Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P35505) Fumarylacetoacetate hydrolase, FAH, N-terminal domainsearch, FAHsearch Fumarylacetoacetate hydrolase, FAH, N-terminal domain.search, Fumarylacetoacetate hydrolase, domain 2search PF01557: Fumarylacetoacetate (FAA) hydrolase familysearch, PF09298: Fumarylacetoacetase N-terminalsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P35505) metabolic processsearch aromatic amino acid family metabolic processsearch L-phenylalanine catabolic processsearch arginine catabolic processsearch tyrosine catabolic processsearch fumarylacetoacetase activitysearch catalytic activitysearch metal ion bindingsearch hydrolase activitysearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Fumarylacetoacetase, C-terminalsearch Fumarylacetoacetasesearch Fumarylacetoacetase, C-terminal-relatedsearch Fumarylacetoacetase, N-terminalsearch