› 1hy9

Solution NMR

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT

Released:
DOI: 10.2210/pdb1hy9/pdb
PDB entry 1hy9 coloured by chain, ensemble of 10 models, front view.
PDB entry 1hy9 coloured by chain, ensemble of 10 models, side view.
PDB entry 1hy9 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.
Ludvigsen S, Thim L, Blom AM, Wulff BS
Biochemistry 40 9082-8 (2001)
PMID: 11478874

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CART(42-89) Chain: A
Molecule details ›
Chain: A
Length: 41 amino acids
Theoretical weight: 4.4 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q16568 (Residues: 76-116; Coverage: 46%)
Gene names: CART, CARTPT
Sequence domains: Cocaine and amphetamine regulated transcript protein (CART)
Structure domains: CART, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry anD simulted annealing
Expression system: Saccharomyces cerevisiae

Quick links

Citations

4 review citations

CART peptides: regulators of body weight, reward and other functions.
Rogge et al. (2008)
3 more

4 mentions without citation

Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression.
Meng et al. (2018)
3 more